Clinical Efficacy and Safety Profile of Prucalopride in Chronic Idiopathic Constipation
نویسندگان
چکیده
منابع مشابه
Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation
Background Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase III study evaluated the efficacy and safety of plecanatide versus placebo in CIC. Methods Adults meeting modified Rome III CIC criteria were rand...
متن کاملEffect of prucalopride on symptoms of chronic constipation
BACKGROUND Prucalopride is a 5-HT4 receptor agonist with gastrointestinal prokinetic activities. This integrated analysis of data from three 12-week, double-blind trials evaluated the effect of prucalopride 2 mg q.d. on common constipation symptoms in women in whom laxatives had failed to provide adequate relief. The effect of prucalopride on bowel function was outside the scope of the analysis...
متن کاملSevere chronic constipation of young women: 'idiopathic slow transit constipation'.
A series of 64 women complaining of severe constipation is described, in each of whom delayed elimination of markers from the colon was demonstrated but a barium enema was normal. All completed a detailed questionnaire and the responses are compared with those obtained in an age-matched series of healthy women with no bowel complaint. In each group 40 women also recorded in a manner suitable fo...
متن کاملProfile of clinical efficacy and safety of topical tacalcitol.
Several topical treatments such as ointments, keratolytics, dithranol, tar, corticosteroids and Vitamin D3 analogues are commonly used in the treatment of mild and/or moderate psoriasis. These treatments can be associated with a variety of local and systemic side effects, as well as to very often unsatisfactory results. The purpose of this critical review of the literature is to evaluate the ef...
متن کاملPrucalopride: the evidence for its use in the treatment of chronic constipation
INTRODUCTION Chronic constipation is a common condition that is difficult to treat. Existing options for the treatment of patients with different subgroups of constipation are limited. A new efficacious and safe drug is needed to limit the frequently observed adverse effects induced by laxatives, to improve general wellbeing and quality of life, and to provide an alternative for enemas or even ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cureus
سال: 2019
ISSN: 2168-8184
DOI: 10.7759/cureus.4382